Keywords

• Bedaquiline fumarate
• Bedaquiline fumaratesupplier
• Bedaquiline fumarate factory

Quick Details

• ProName: Factory Supply Bedaquiline fumarate Su...
• CasNo: 845533-86-0
• Molecular Formula: C36H35BrN2O6
• Appearance: white Powder
• Application: Pharma;Industry;Agricultural;chemical ...
• DeliveryTime: 1~2 weeks after confirm order
• PackAge: 25kg,50kg,180kg,200kg,250kg,1000kg，cus...
• Port: Any port in China
• ProductionCapacity: 15 Metric Ton/Month
• Purity: 99%+
• Storage: Keep it in dry,shady and cool place
• Transportation: Transit could be DHL,UPS,TNT,EMS,Fedex...
• LimitNum: 1 Kilogram

Superiority

1,we produce and sell good chemicals around the world.
2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.
3,our staff consists of highly qualified individuals with bsc, msc and ph.d degrees in chemistry, as well as excellent carbohydrates,nucleosides, small molecules and rare chemicals.
4,imaginechem's chemists are skilled at performing complex, multi-step syntheses and solving difficult chemistry-related problems. because of our better, concentracted size and low overheads, we are able to offer prompt quotations, very competitive prices, high quality products and fast delivery.
5,all chemicals are typically >97% for building blocks, the structure and purity is confirmed by nmr and lc-ms. intermediates and final products are analyzed by gc, hplc, ir, nmr, ms, elemental analysis, atom-absorpting analysis and crystallographical methods.
165,Customers-oriented strategy, exclusive supply chain management, professional R&D team, experienced production workers, energetic sales team enable us to offer best service andgood-value products to all of our customers and gradually reach our final goals: becoming global leading supplier for portable products and solutions.

Details

Product Name:    Bedaquiline fumarate
Synonyms:    (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol fumarate;(1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol (2E)-2-butenedioate (1:1);Bedaquiline Fumarate salt;Bedaquiline (fuMarate);R 403323;(1R,2S)-1-(6-broMo-2-Methoxyquinolin-3-yl)-4-(diMethylaMino)-2-naphthalen-1-yl-1-phenylbutan-2-ol,(E)-but-2-enedioic acid;TMC-207;TMC207;TMC 207;(1R,2S)-1-(6-bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthalenyl)-1-phenyl-2-butanol
CAS:    845533-86-0
MF:    C36H35BrN2O6
MW:    671.59 
Description    Bedaquiline fumarate (BQF) is an FDA-approved antituberculosis drug that targets the enzyme ATP synthase. It is a fumarate salt prepared from equimolar amounts of bedaquiline and fumaric acid. It can be used in combination therapy for the treatment of multidrug-resistant tuberculosis in the lungs of adults (18 years of age and older). The new BQF microemulsion dosage form of BQF has improved oral bioavailability over the previous formulation, and the BQF microemulsion is cytocompatible with significantly higher cellular uptake than the control group at the highest concentration of 500 μg/ml, which could lead to further use in the effective treatment of multidrug-resistant tuberculosis[1].
Definition    ChEBI: Bedaquiline fumarate is a fumarate salt prepared from equimolar amounts of bedaquiline and fumaric acid. It is used in combination therapy for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria. It has a role as an antitubercular agent and an ATP synthase inhibitor. It contains a bedaquiline(2+).

Wuhan Circle Star Bio-medic Technology co.,Ltd is located in wuhan, the central city of  China, the core of the Changjiang river economic belt and known as the "thoroughfare of nine provinces".

   The company has two laboratories,  a apilot plant (located in wuhan), and two amplification production bases (located in hubei).The company employs a number of professor, doctors and professors from wuhan university, Wuhan University of Technology, huazhong university of science and technology and other famous universities in China to form the R&D team, and also has its own excellent sales team.

    The company always adhere to the " quality first  customer first, quality after-sales service" professional philosophy and enterprise spirit. The company can provide excellent products, technical support and perfect after-sales service, and ensure the quality and timely delivery regardless of business size.In order to establish a good reputation among domestic and foreign customers.