Keywords

• Drospirenone
• Drospirenone supplier
• Drospirenone factory

Quick Details

• ProName: Factory Supply Drospirenone Supplier M...
• CasNo: 67392-87-4
• Molecular Formula: C24H30O3
• Appearance: white Powder
• Application: Pharma;Industry;Agricultural;chemical ...
• DeliveryTime: 1~2 weeks after confirm order
• PackAge: 25kg,50kg,180kg,200kg,250kg,1000kg，cus...
• Port: Any port in China
• ProductionCapacity: 15 Metric Ton/Month
• Purity: 99%+
• Storage: Keep it in dry,shady and cool place
• Transportation: Transit could be DHL,UPS,TNT,EMS,Fedex...
• LimitNum: 1 Kilogram

Superiority

1,we produce and sell good chemicals around the world.
2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.
3,our staff consists of highly qualified individuals with bsc, msc and ph.d degrees in chemistry, as well as excellent carbohydrates,nucleosides, small molecules and rare chemicals.
4,imaginechem's chemists are skilled at performing complex, multi-step syntheses and solving difficult chemistry-related problems. because of our better, concentracted size and low overheads, we are able to offer prompt quotations, very competitive prices, high quality products and fast delivery.
5,all chemicals are typically >97% for building blocks, the structure and purity is confirmed by nmr and lc-ms. intermediates and final products are analyzed by gc, hplc, ir, nmr, ms, elemental analysis, atom-absorpting analysis and crystallographical methods.
165,Customers-oriented strategy, exclusive supply chain management, professional R&D team, experienced production workers, energetic sales team enable us to offer best service andgood-value products to all of our customers and gradually reach our final goals: becoming global leading supplier for portable products and solutions.

Details

Factory Supply Drospirenone Supplier Manufacturer In Stock Good Price

Product Name:    Drospirenone
Synonyms:    17-Hydroxy-7β-(hydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21-carboxylic Acid, -Lactone;7β-(HydroxyMethyl)-15β,16β-Methylene-17α-pregn-3,5(6)-diene-21,17-carbolactone;Drospirenone(Dihydrospirorenone);Spiro[17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthrene-17,2'(5'H)-furan]-3,5'(2H)-dione;Drospirenone (USP32);Drospirenone, >=98%;Drosporenone;6b,7b:15b,16b-Dimethylen-3-oxo-17a-pregn-4-ene-21
CAS:    67392-87-4
MF:    C24H30O3
MW:    366.5
EINECS:    266-679-2
Description    Drospirenone is a synthetic progestogen that binds to the progesterone, mineralocorticoid, and androgen receptors with binding affinities of 20, 230, and 65% relative to R5020, aldosterone , and R1881, respectively. In vivo, drospirenone inhibits spontaneous ovulation in rats (ID50s = 0.3-1.0 mg/day) when administered orally or subcutaneously. Drospirenone (0.5 mg/animal) administered six times per day maintains pregnancy in ovariectomized pregnant rats. It reduces serum testosterone (Item Nos. 15645 | ISO60154) and luteinizing hormone in cynomolgus monkeys in a dose-dependent manner. Drospirenone (10 mg/animal per day) also inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats. Formulations containing drospirenone have been used as oral contraceptives.
Description    The steroid drospirenone in combination with the estrogen agonist ethinylestradiol was introduced in Germany as a new oral contraceptive for women. This analog of the aldosterone antagonist spironoiactone can be synthesized in five steps from 3β-hydroxy- 15β,16β-methylene-5-androsten-l7-one. Since its binding profile for steroid receptors is very similar to progesterone, drospirenone mimics the progestogen agonistic activity as well as the anti-androgenic and anti-mineralocorticoid properties of the endogenous hormone. In rats, drospirenone inhibited ovulation at 6.3 mglkglday p.o. Compared with currently available progestins which lack anti-mineralocorticoid activity, drospirenone did not cause weight gain that could result from fluid retention in clinical studies. Its combination with ethinylestradiol was well tolerated and did not engender adverse effects on blood pressure or plasma lipid levels. Drospirenone is rapidly absorbed in man with an oral bioavailability of 76%. It is extensively metabolized since over 20 different metabolites were observed in the urine and in the feces, resulting for instance from hydrolysis of the lactone in the plasma or reductive conjugation of the enone to the 3-sulfate ester of 45 dihydrodrospirenone. Its elimination is bi-exponential with an initial and a terminal half-life of 2 and 25-33h respectively.

Wuhan Circle Star Bio-medic Technology co.,Ltd is located in wuhan, the central city of  China, the core of the Changjiang river economic belt and known as the "thoroughfare of nine provinces".

   The company has two laboratories,  a apilot plant (located in wuhan), and two amplification production bases (located in hubei).The company employs a number of professor, doctors and professors from wuhan university, Wuhan University of Technology, huazhong university of science and technology and other famous universities in China to form the R&D team, and also has its own excellent sales team.

    The company always adhere to the " quality first  customer first, quality after-sales service" professional philosophy and enterprise spirit. The company can provide excellent products, technical support and perfect after-sales service, and ensure the quality and timely delivery regardless of business size.In order to establish a good reputation among domestic and foreign customers.